346

(b) Oncolytic virus

You can find information here:

–– https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4303349/

–– https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4105246/

–– https://www.genelux.com/leadership-­in-­oncolytic-­virotherapy/oncolytic-­

virotherapy/.

Best to browse the internet yourself.

Question 13.8

Here is the link to DrumPID (https://drumpid.bioapps.biozentrum.uni-wuerzburg.de/com­

pounds/index.php), which is a database that combines protein interactions with drugs (i.e.

chemical compounds). Here you can easily compare main and side effects, protein interac­

tions and pharmaceuticals.

Here is the related publication along with the tutorial: https://database.oxfordjournals.

org/content/2016/baw041.full. Also work through this database and the tutorial.

Another interesting and powerful database in this direction is the STITCH database

at EMBL:

https://nar.oxfordjournals.org/content/early/2015/11/19/nar.gkv1277.full.pdf

https://stitch.embl.de

Question 13.9

Here are four beautiful breakthroughs gathered together:

Adleman LM (1994) Molecular Computation of Solutions to Combinatorial Problems.

Science 266: 1021–1024. Leonard Adelman deserves credit for having recreated the trav­

eling salesman problem for simple cases (up to six cities) in DNA molecules by ligation.

Zimmer R (1998) Patent on parallel, universal and free-programmable information sys­

tem for general computing operations. WO9847077 (A1) 1998 Oct 22. Prof. Ralph

Zimmer (LMU Munich) considered how to convert the lambda calculus into a universal

calculating machine and implement it in living organisms.

Win MN, Smolke CD (2008) Higher-order cellular information processing with syn­

thetic RNA devices. Science 322, 456–460. Here, RNA aptamers that measure caffeine

and diazepam have been interconnected with an RNA lever in such a way that they act like

mini-sensors, switching to start only when the concentrations of either have a suit­

able range.

Tero A, Takagi S, Saigusa T et al. (2010) Rules for biologically inspired adaptive net­

work design. Science. 2010 Jan 22; 327(5964): 439–442. https://doi.org/10.1126/sci­

ence.1177894. The latest work calculates the optimal plan for the Tokyo metro system

with the help of a slime mold that has been suitably distributed food.

20  Solutions to the Exercises